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Yes, all kitten and puppy milk replacers must be refrigerated after opening. Esbilac® and KMR® powders are milk-based and contain fat, therefore have the potential to spoil under certain conditions. They can also experience bacterial growth when stored improperly. The can of powder has to be kept in the refrigerator or freezer after it has been opened. The powders will keep in the refrigerator for up to 3 months, or in the freezer for up to 6 months.View all FAQs